Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects-Reference-Cited by-同舟云学术

Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects

Published:2023-06 Issue:4 Volume:16 Page:507-516
ISSN:1874-4672
Container-title:Current Molecular Pharmacology
language:en
Short-container-title:CMP

Author:

Rahmani Mohammad Reza¹,Zamanian Mohammad Yassin²,Karimvandi Mahdi Najafiani³,Nikbakhtzadeh Marjan⁴,Zahedi Elham⁴,Bokov Dmitry Olegovich⁵,Kujawska Małgorzata⁶,Heidari Mahsa⁷

Affiliation:

1. Department of Physiology and Pharmacology, School of Medicine, Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

3. Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.

4. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

5. Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation

6. Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland

7. Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran

Abstract

Abstract: Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is a stimulant-like medicine used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing activity of MOD in experimental and clinical studies. We included behavioral evaluations alongside the effects of MOD at the cellular and molecular level. MOD in different animal disease models exerted beneficial effects on induced memory and learning impairment, which in some cases were accompanied by modulation of neurotransmitter pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins. Individuals treated with MOD showed improved memory and learning skills in different conditions. These effects were associated with regulating brain activity in some participants, confirmed by functional magnetic resonance imaging. Presented herein, data support the use of MOD in treating memory and learning deficits in various disease conditions.

Publisher

Bentham Science Publishers Ltd.

Subject

General Health Professions