Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation

Author:

Khalil Mohamad1,Martemucci Giovanni2,Portincasa Piero1,Centonze Vincenzo1,Mariano Michele3,D'Alessandro Angela Gabriella2

Affiliation:

1. Clinica Medica “A. Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy

2. Department of Agricultural and Environmental Sciences, University of Bari Aldo Moro, Via G. Amendola, 165/A - 70126 Bari, Italy

3. Unità Operativa Complessa di Radiodiagnostica Universitaria, Policlinico di Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy

Abstract

Abstract: Excessive and uncontrolled oxidative stress can damage biomacromolecules, such as lipids, proteins, carbohydrates, and DNA, by free radical and oxidant overproduction. In this review, we critically discuss the main properties of free radicals, their implications in oxidative stress, and specific pathological conditions. In clinical medicine, oxidative stress can play a role in several chronic noncommunicable diseases, such as diabetes mellitus, cardiovascular, inflammatory, neurodegenerative diseases, and tumours. Antioxidant supplements can theoretically prevent or stop the progression of diseases, but a careful literature analysis finds that more evidence is needed to dissect the ultimate beneficial effect of antioxidants versus reactive oxygen species in several diseases.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery

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