Computational Analysis of Marburg Virus Envelope Glycoproteins: Insights from Bioinformatics and Genomics-Reference-Cited by-同舟云学术

Computational Analysis of Marburg Virus Envelope Glycoproteins: Insights from Bioinformatics and Genomics

Published:2024-07-10 Issue: Volume:20 Page:
ISSN:1573-4110
Container-title:Current Analytical Chemistry
language:en
Short-container-title:CAC

Author:

Polanco Carlos¹²,Huberman Alberto³,Uversky Vladimir N.⁴,Rios Castro Martha¹,Becerra-Luna Brayans¹,Lemus Enrique Hernandez⁵,Pimentel-Hernández Claudia⁶,Martínez-Garcia Mireya⁷,Buhse Thomas⁸,Juárez Cynthia Karen Gutierrez⁹,Alarcon Gilberto Vargas¹⁰,Corona Gabriela Calvo-Leroux¹¹,Roldan Gomez Francisco J.¹¹,Díaz-González Juan Luciano¹²,Martinez-Memije Raul⁹,Flores Ch Pedro L.⁹

Affiliation:

1. Department of Electromechanical Instrumentation, Instituto Nacional de Cardiologia 'Ignacio Chavez,' Mexico City, 14080, Mexico

2. Department of Mathematics, Faculty of Sciences, Universidad Nacional Autonoma de Mexico, Mexico City, 04510, Mexico

3. Department of Biochemistry, Instituto Nacional de Ciencias Medicas y Nutricion 'Salvador Zubiran', 14080, Mexico City, Mexico

4. Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, 33647, USA

5. Department of Computational Genomics, Instituto Nacional de Medicina Genomica, Mexico City, 14610, Mexico

6. Clinical Research Support Unit, Instituto Nacional de Pediatria, Mexico City, 04530, Mexico

7. Department of Immunology, Instituto Nacional de Cardiologia 'Ignacio Chavez,' Mexico City 14080, Mexico

8. Chemical Research Center, Universidad Autonoma del Estado de Morelos, Cuernavaca, Morelos, 62209, Mexico

9. Department of Electromechanical Instrumentation, Instituto Nacional de Cardiologia 'Ignacio Chavez,' Mexico City, 14080, Mexico

10. Department of Molecular Biology and Research Direction, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City, 14080, Mexico

11. Outpatient Clinic, Instituto Nacional de Cardiologia 'Ignacio Chavez', Mexico City, 14080, Mexico

12. Secretaría Tecnica de Computo, Redes y Telecomunicaciones, Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Mexico City, 04510, Mexico

Abstract

Background: Marburg virus (MARV), which is spread by one species of fruit bats, can cause deadly Marburg virus disease (MVD, also known as Marburg hemorrhagic fever, MHF), which is a severe form of viral hemorrhagic fever with symptoms similar to Ebola. MARV is considered to be very dangerous, and there are no approved vaccines or antiviral treatments for Marburg disease. Objective: Computational studies were conducted to comprehend the envelope glycoproteins GP1 and GP2 expressed by the Marburg virus. Methods: Determination of the predicted intrinsic disorder predisposition of each glycoprotein sequence (PIDP) and the Polarity Index Method Profile 3.0v (PIM 3.0v) using genomics software and multiple computer algorithms, several of which have been specifically designed for this purpose. Results: The PIM 3.0v and PIDP profiles showed different MARV envelope glycoprotein patterns. These patterns revealed structural and morphological commonalities. Conclusions: Our computer systems were able to identify MARV envelope glycoprotein isolates using the PIM 3.0v profile, and they suggest that they can be used as a first-step filter for identifying them from databases or building synthetic proteins.

Publisher

Bentham Science Publishers Ltd.