Affiliation:
1. Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box-33, Postal Code-616, Birkat Al-Mauz,
Nizwa, Sultanate of Oman
2. Organic Chemistry, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Str. 2, D-
06120, Halle (Saale), Germany
Abstract
Background:
A variety of natural products reveal the presence of the 1H-1,2,3-triazole
moiety in their chemical structures. In general, these molecules also play a significant role in the
agrochemical, medicinal and pharmaceutical industries. Microwave-assisted reactions have attracted
great interest for researchers to synthesize 1H-1,2,3-triazole compounds in shorter times with
increased yields.
Objective:
The objective of this study is to optimize the purity and yield of the product, shorter the
reaction time, and make the reaction more eco-friendly with the help of microwave-assisted organic
synthesis.
Methods:
The present work elucidates a very simple but efficient and rapid, highly productive
synthesis of various substituted 1H-1,2,3-triazole series, using the Suzuki-Miyaura cross-coupling
reaction, employing microwave irradiation in water with tetrabutylammonium bromide (TBAB).
Utilizing (S)- (-) ethyl lactate as the starting material, the synthesis of the substituted 1H-1,2,3-
triazole aryl bromide (1) was achieved.
Results:
This compound (1) was subjected to the Suzuki-Miyaura cross-coupling reaction under
microwave irradiation, using a variety of aryl boronic acids in an aqueous medium, to attain high
yields of the target products, namely 3a-w. Overall, this is an environmentally benign, very efficient
technique under microwave irradiations as a green and eco-friendly source. Only those methodologies
that involve microwave-assisted reactions during synthesis in a related manner have
been reviewed.
Conclusion:
Microwave-assisted Suzuki-Miyaura cross-coupling reactions in the water of substituted
1H-1,2,3-triazole series can be employed to quickly explore and increase molecular diversity
in synthetic chemistry. In this respect, microwave-mediated methods help researchers to make
helpful studies.
Funder
The Oman Research Council
Publisher
Bentham Science Publishers Ltd.
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