A Novel Idea of Sulfamic Acid as an Efficient Catalyst for the Synthesis of
2-Azapyrrolizidine Derivatives
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Published:2023-02
Issue:1
Volume:10
Page:19-25
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ISSN:2213-3372
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Container-title:Current Organocatalysis
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language:en
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Short-container-title:COCAT
Author:
Tafer Radia1,
Boulcina Raouf1,
Debache Abdelmadjid1
Affiliation:
1. Laboratory of Synthesis of Molecules with Biological Interest, Mentouri-Constantine University, 25000 Constantine,
Algeria
Abstract
Background:
The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities.
Objective:
An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via three-component reaction.
Methods:
The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved.
Results:
The present protocol leads in most cases to the desired products in high yields.
Conclusion:
The synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Analytical Chemistry,Catalysis