Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma-Reference-Cited by-同舟云学术

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Published:2022-08-26 Issue:9 Volume:22 Page:725-740
ISSN:1568-0096
Container-title:Current Cancer Drug Targets
language:en
Short-container-title:CCDT

Author:

Nath Lekshmi R.¹^ORCID,Kumar Ayana R.¹,Devan Aswathy R.¹,Nair Bhagyalakshmi¹,Nair Reshma Ravindran²

Affiliation:

1. Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi-682041, Kerala, India

2. Wellcome Centre for Cell Biology, University of Edinburgh, Scotland, United Kingdom

Abstract

Abstract:Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC. HCC cells maintain an immune-suppressive environment with the help of immunesuppressive tumor-associated antigens, resulting in a metastatic spread of the disease. The development of intense immunotherapeutic strategies to target tumor-associated antigen is critical to overcoming the progression of HCC. MUC 1 remains the most recognized tumor-associated antigen since its discovery over 30 years ago. A few promising immunotherapies targeting MUC 1 are currently under clinical trials, including CAR-T and CAR-pNK-mediated therapies. This review highlights the biosynthesis, significance, and clinical implication of MUC 1 as an immune target in HCC.

Funder

Amrita Vishwa Vidyapeetham

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Drug Discovery,Pharmacology,Oncology

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