Affiliation:
1. Department of Pharmacology, Parul Institute of Pharmacy, Parul University, Gujarat, India
2. Department of Pharmacy
Practice, Parul Institute of Pharmacy, Parul University, Gujarat, India
Abstract
Abstract:
OSCC (Oral Squamous Cell Carcinoma) is a major health challenge in many parts of the
world. It occurs most commonly in males and is associated with tobacco, pan, or areca nut consumption.
One of the major challenges associated with the management of OSCC is late diagnosis. As a
result, the treatment required is more aggressive, expensive, and has poor prognostic value. On the
other hand, early diagnosis of OSCC can be life-saving with less aggressive treatment and a better
prognosis.
:
A diagnostic method for early diagnosis of OSCC is greatly needed. A lot of research efforts have
been made to identify biomarkers that can act as tools to classify the tumor status of the patient. Various
biological fluids and tissues have been explored for such studies. Saliva appears to be the most
attractive biological sample with many potential advantages over other matrices such as blood or tissue.
Saliva as a diagnostic fluid has the advantage of ample availability, being non-invasive and being
in the vicinity of the tumor, and having a less complex composition. Our paper provides an updated
review of the state of the art of research in the area of salivary biomarkers for oral squamous cell carcinoma.
The paper gives an account of methods for saliva collection, followed by a brief description of
various protein biomarkers discovered to date, along with their status quo.
Publisher
Bentham Science Publishers Ltd.
Subject
Cancer Research,Drug Discovery,Pharmacology,Oncology
Cited by
2 articles.
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