Affiliation:
1. Department of Chemistry, School of Basic and Applied Sciences, Maharaja Agrasen University, Baddi (H.P.)-174103,
India
Abstract
Background:
Polysaccharide based gastro-retentive drug delivery systems (GRDDSs) can retain in the gastric
fluid of stomach for longer time and release entrapped drug in controlled and localized manner, which can ensure optimal
drug concentration at the site of action with improved bioavailability and reduced side effects of acid suppressive drugs
like ranitidine.
Objective:
The objective of present study was to design smart polymers for gastro-retentive drug delivery of ranitidine
through ionic-gelation of carboxymethyl cellulose (CMC) and sodium alginate (ALG).
Methods:
The optimal reaction conditions for synthesis of beads were evaluated by varying reaction parameters during
synthesis and were obtained as [CMC] = 1.5% (w/v), [ALG] = 0.5% (w/v) and [CaCl2] = 0.1 M with maximum
equilibrium swelling ratio (2922.50±0.90)%. The drug loading was carried out by simultaneous and swelling equilibrium
methods. Beads were characterized by SEM, PXRD, FTIR, TGA, bead size and swelling studies.
Results:
Increase in Ca2+ ions and ALG concentration resulted in decrease in swelling capacity and increase in bead size.
Beads got collapsed in phosphate buffer solution and swelling had been occurred through non-Fickian diffusion
mechanism. Floating beads with (51.05±0.25)% entrapment efficiency for simultaneous drug loading method exhibited
Fickian diffusion mechanism and best fitted in Higuchi model. The diffusion coefficient and initial rate of drug release in
simulated gastric fluid demonstrated swelling controlled gastro-retentive release of ranitidine.
Conclusion:
These smart polymeric beads have potential to use as a promising candidate for the design of GRDDSs
meant for the treatment of gastric ulceration and gastro-oesophageal reflux disease.
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Developmental Biology,Embryology,Anatomy
Cited by
2 articles.
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