Affiliation:
1. School of Medicine, University of Zagreb, Salata 12, 10000, Zagreb, Croatia
2. University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, 10000, Zagreb, Croatia, Croatia
Abstract
Background:
Ondansetron and paracetamol are often co-administrated to prevent and treat
nausea and vomiting caused by anaesthesia and to control postoperative pain. In addition, ondansetron
is used as the first-line antiemetic in paracetamol overdose. Therefore, a selective and sensitive
method for their simultaneous analysis is of great importance. The electroanalytical methods are
highly sensitive and offer many possibilities for new sensor platform design. However, at present, no
electroanalytical method for simultaneous determination of these drugs has been proposed.
Objective:
The aim of this study was to develop a novel nanosensor for selective monitoring of ondansetron
and paracetamol in pharmaceutical and biological samples without expensive and timeconsuming
pretreatments.
Methods:
The graphitized multi-walled carbon nanotubes embedded in a cation exchange polymer
matrix were selected, among various surface functionalizations evaluated, to design a novel sensor.
Based on its excellent sensing performance, the first electroanalytical method was developed for the
rapid concurrent determination of investigated drugs.
Results:
The scanning electron microscopy study showed an interlinked nanoporous network structure
and a highly enlarged active surface. The developed sensor facilitated electron transfer in the
oxidation of both drugs and tremendously enhanced the adsorption capacity for ondansetron, thus
exhibiting a significant increase in drug responses and sensitivity. To obtain much sensitive response
of investigated drugs, the effect of pH values of supporting electrolyte, dispersed nanomaterial
amount, the cation exchange polymer concentration, drop-casting volume of nanocomposite suspension,
accumulation potential and deposition time on the peak current was evaluated. The developed
electroanalytical method was validated and the practical utility of the proposed nanosensor was
tested.
Conclusion:
The developed sensor is a promising sensing platform with a fast response time for
analysis of ondansetron and paracetamol at very different concentration levels found in their fixeddose
combination and human serum sample after recommended daily doses showing its potential
usage in pharmaceutical quality control and clinical research.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Cited by
1 articles.
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