Affiliation:
1. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, India
Abstract
Background:
In the diagnosis, management and treatment of cancer, numerous technological advancements have
been explored in the past few years to find better applications over the conventional treatment approaches. However, their
implementation in clinical practice leads to severe and toxic effects to the healthy tissues. Drugs in the form of actives
impart cytotoxic effect but concurrently produce undesirable changes on normal tissues. Moreover, serum half-life and
intra-tumor accumulation limit an effective cancer treatment for therapeutic agents.
Objective:
The objective of this review is to promote the significance of nanotherapy in cancer by strategizing drug-free
macromolecules in contrast to conventional methodologies.
Methods:
This unique concept covers molecularly-imprinted polymers, nanopolymer complex systems, metal nanoparticles,
carbon nanotubes, quantum dots, grafted polymer-based systems and drug-free macromolecular therapeutics for effective
and selective therapeutic action.
Results:
In advance drug delivery systems, target-specific therapy indicates great potential to improve the efficacy of
therapeutics by reducing adverse events to other parts of the body, but is restricted due to adverse reactions at the therapeutic
site. To resolve such complications, drug-free nanotherapy approaches act as an alternative system against conventional
carriers for treating organ-specific cancers like head, neck, lung, breast, prostate, kidney, etc.
Conclusion:
The drug-free approaches in various diseases will provide entirely new perception in order to avoid or reduce
the side and adverse effects of drugs.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献