Electrochemical Nanomaterial-based Sensors/Biosensors for Drug Monitoring

Author:

Negahdary Masoud1,Angnes Lúcio1,Barros Azeredo Nathália Florência1,Santos Berlane Gomes1,de Oliveira Thawan Gomes1,de Oliveira Lins Renato Soares1,dos Santos Lima Irlan1

Affiliation:

1. Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. 05508-000, São Paulo, Brazil

Abstract

Abstract: Determining the amount of medication used is essential for correctly managing treatment systems. The unauthorized use of drugs and the importance of determining the absorbed and re-quired dose of drugs in target organs are essential factors that justify the design of new drug moni-toring systems. Electrochemical sensors and biosensors based on nanomaterials have been devel-oped for drug monitoring in the past few years. The use of nanomaterials to optimize the analyte de-tection process and facilitate electron transfer in electrochemical processes has enhanced intermo-lecular interactions and increased diagnostic sensitivity. Considering this review, in the first part, the evaluation of cancer drugs is examined, which can be used to determine the exact dose of the drug required in different stages of cancer. Accurate monitoring of cancer drugs can increase patient life expectancy, reduce side effects, and increase economic savings. In the next section, sensors and biosensors designed for antibiotics are examined. Accurate measurement of antibiotics for deter-mining the effectiveness of the dose in controlling infections and preventing antibiotic resistance is possible with the help of these drug diagnostic platforms. In the next part, the diagnosis of different hormones is considered. Abnormal amounts (low/high) of hormones cause multiple physiological complications and various disabilities. Therefore, accurate determination of hormone levels can ef-fectively treat hormonal changes. In the last section, other drugs, including drugs and analgesics for which the use of electrochemical diagnostic platforms can significantly help drug distribution and social health systems, are also discussed.

Funder

São Paulo Research Foundation-FAPESP

National Council for Research-CNPq

Capes Program, PROEX

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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