Affiliation:
1. Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, 495009, India
2. Department
of Pharmaceutical Chemistry, Apollo College of Pharmacy, Durg, 491001, India
Abstract
Abstract:
Multi-target drug development (MTDD) is the demand of the recent era, especially in
the case of multi-factorial conditions such as cancer, depression, neurodegenerative diseases (NDs),
etc. The MTDD approaches have many advantages; avoidance of drug-drug interactions, predictable
pharmacokinetic profile, and less drug resistance. The wet lab practice in MTDD is very
challenging for the researchers, and the chances of late-stage failure are obvious. Identification of
an appropriate target (Target fishing) is another challenging task in the development of multi-target
drugs. The in silico tools will be one of the promising tools in the MTDD for the NDs. Therefore
the outlook of the review comprises a short description of NDs, target associated with different
NDs, in silico studies so far done for MTDD for various NDs. The main thrust of this review is to
explore the present and future aspects of in silico tools used in MTDD for different NDs in combating
the challenge of drug development and the application of various in silico tools to solve the
problem of target fishing.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
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