Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer

Abstract

Background: Polypharmacology means drugs having interactions with multiple targets of a unique disease or many disease pathways. This concept has been greatly appreciated against complex diseases, such as oncology, CNS disorders, and anti-infectives. Methods: The integration of diverse compounds available on public databases initiates polypharma-cological drug discovery research. Immunocompromised patients may suffer from complex diseas-es. Multiple-component drug formulations may produce side effects and resistance issues due to un-intended drug-target interactions. Results: Polypharmacology remains a novel avenue to propose a more effective and less toxic treatment. The 4-amino quinoline scaffold has become an important construction motif for the de-velopment of new drugs against lifestyle diseases like cancer and infectious diseases like tuberculo-sis and malaria. Conclusion: The present study is an attempt to explore the polypharmacological effects of 4-aminoquinoline drugs to combat malaria, cancer, and tuberculosis.