Targeting Tubulin-colchicine Site for Cancer Therapy: Inhibitors, Antibody- Drug Conjugates and Degradation Agents
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Published:2019-09-03
Issue:15
Volume:19
Page:1289-1304
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ISSN:1568-0266
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Container-title:Current Topics in Medicinal Chemistry
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language:en
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Short-container-title:CTMC
Author:
Duan Yongtao1, Liu Wei1, Tian Liang1, Mao Yanna1, Song Chuanjun2
Affiliation:
1. Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China 2. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450001, China
Abstract
Microtubules are essential for the mitotic division of cells and have been an attractive target
for antitumour drugs due to the increased incidence of cancer and significant mitosis rate of tumour cells.
In the past few years, tubulin-colchicine binding site, as one of the three binding pockets including taxol-,
vinblastine- and colchicine-binding sites, has been focused on to design tubulin-destabilizing agents including
inhibitors, antibody-drug conjugates and degradation agents. The present review is the first to
cover a systemic and recent synopsis of tubulin-colchicine binding site agents. We believe that it would
provide an increase in our understanding of receptor-ligand interaction pattern and consciousness of a
series of challenges about tubulin target druggability.
Funder
Henan Medical Science and Technology Program Henan Province Postdoctoral Science Foundation National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
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