Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids

Abstract

Abstract: Flavonoids are secondary metabolites of plants. In general，most flavonoids are combined with glucosides and have extremely complex molecular structures. In the nature，these flavonoids have a variety of biological activities，such as anti-oxidation，anti-virus，anti-tumor，scavenging free radicals and so on，however，due to poor solubility and stability of flavonoids，their bioavailability is limited. The method of drug design is used to modify the structure of flavonoids to give them special functions. At present, flavonoids have broad application prospects in the treatment of tumors. It has inhibited the proliferation, migration, invasion, angiogenesis and multi-drug resistance of tumors and has become a research hotspot.