Affiliation:
1. Laboratório de Diversidade Molecular e Química Medicinal (LaDMol-QM, Molecular Diversity and Medicinal
Chemistry Laboratory), Chemistry Institute, Universidade Federal Rural do Rio de Janeiro, Seropédica, Rio de Janeiro,
23897-000, Brazil | Programa de Pós-Gradução em Química (PPGQ), Universidade Federal Rural do Rio de
Janeiro, Seropédica, Rio de Janeiro, 23897-000, Brazil
Abstract
Abstract:
Cardiovascular diseases (CVDs) comprise a group of diseases and disorders of the heart
and blood vessels, which together are the number one cause of death worldwide, being associated
with multiple genetic and modifiable risk factors, and that may directly arise from different etiologies.
For a long time, the search for cardiovascular drugs was based on the old paradigm “one compound -
one target”, aiming to obtain a highly potent and selective molecule with only one desired molecular
target. Although historically successful in the last decades, this approach ignores the multiple causes
and the multifactorial nature of CVDs. Thus, over time, treatment strategies for cardiovascular diseases
have changed, and, currently, pharmacological therapies for CVD are mainly based on the association
of two or more drugs to control symptoms and reduce cardiovascular death. In this context,
the development of multitarget drugs, i.e., compounds having the ability to act simultaneously at multiple
sites, is an attractive and relevant strategy that can be even more advantageous to achieve predictable
pharmacokinetic and pharmacodynamics correlations as well as better patient compliance. In
this review, we aim to highlight the efforts and rational pharmacological bases for the design of some
promising multitargeted compounds to treat important cardiovascular diseases like heart failure, atherosclerosis,
acute myocardial infarction, pulmonary arterial hypertension, and arrhythmia.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献