Affiliation:
1. Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan
Abstract
The liver is a vital organ for life and the only internal organ that is capable of natural regeneration.
Although the liver has high regeneration capacity, excessive hepatocyte death can lead to liver
failure. Various factors can lead to liver damage including drug abuse, some natural products, alcohol,
hepatitis, and autoimmunity. Some models for studying liver injury are APAP-based model, Fas ligand
(FasL), D-galactosamine/endotoxin (Gal/ET), Concanavalin A, and carbon tetrachloride-based models.
The regeneration of the liver can be carried out using umbilical cord blood stem cells which have
various advantages over other stem cell types used in liver transplantation. UCB-derived stem cells
lack tumorigenicity, have karyotype stability and high immunomodulatory, low risk of graft versus
host disease (GVHD), low risk of transmitting somatic mutations or viral infections, and low immunogenicity.
They are readily available and their collection is safe and painless. This review focuses on
recent development and modern trends in the use of umbilical cord stem cells for the regeneration of
liver fibrosis.
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
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