Affiliation:
1. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
Abstract
Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various antiproliferative
mechanisms, and some of them, such as Vinblastine and Vincristinem, have already used in clinics
or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important
position in the discovery of novel anticancer agents. This review emphasizes the recent development
of indole alkaloids as potential anticancer agents, their structure-activity relationship, and
mechanisms of action covering the articles published from 2015 to 2020.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
46 articles.
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