Affiliation:
1. Research Department, Beijing Hongtianji Neuroscience Academy, Beijing 100143, China
2. Department of Surgical
Sciences, Int. Exp. CNS Injury & Repair (IECNSIR), Anesthesiology & Intensive Care Medicine, University Hospital,
Uppsala University, SE-75185 Uppsala, Sweden
3. Department of Neurosurgery, Dongzhimen Hospital, Beijing
University of Traditional Chinese Medicine, Beijing 100700, China
Abstract
Abstract:
Neurorestorative treatments have been able to improve the quality of life for patients suffering
from neurological diseases and damages since the concept of Neurorestoratology was proposed.
The discipline of Neurorestoratology focuses on restoring impaired neurological functions and/or
structures through varying neurorestorative mechanisms including neurostimulation or neuromodulation,
neuroprotection, neuroplasticity, neuroreplacement, loop reconstruction, remyelination, immunoregulation,
angiogenesis or revascularization, neuroregeneration or neurogenesis and others. The neurorestorative
strategies of Neurorestoratology include all therapeutic methods which can restore dysfunctions
for patients with neurological diseases and improve their quality of life. Neurorestoratology
is different from regenerative medicine in the nervous system, which mainly focuses on the neuroregeneration.
It also is different from Neurorehabilitation. Neurorestoratology and Neurorehabilitation
share some functional recovering mechanisms, such as neuroplasticity, especially in the early phase of
neurological diseases; but generally Neurorehabilitation mainly focuses on recovering neurological functions
through making the best use of residual neurological functions, replacing lost neurological functions
in the largest degree, and preventing and treating varying complications. Recently, there have been more
advances in restoring damaged nerves by cell therapy, neurostimulation/neuromodulation and braincomputer
interface (BCI), neurorestorative surgery, neurorestorative pharmaceutics, and other clinic
strategies. Simultaneously related therapeutic guidelines and standards are set up in succession. Based on
those advances, clinicians should consider injured and degenerated nervous disorders or diseases in the
central nervous system as treatable or neurorestorative disorders. Extending and encouraging further neurorestorative
explorations and achieving better clinical efficacy with stronger evidence regarding neurorestoratology
will shed new light and discover superior benefits for patients with neurological disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,General Neuroscience
Cited by
5 articles.
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