Heart Failure And Type 2 Diabetes Mellitus: Neurohumoral, Histological
And Molecular Interconnections
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Published:2023-03
Issue:2
Volume:19
Page:
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ISSN:1573-403X
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Container-title:Current Cardiology Reviews
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language:en
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Short-container-title:CCR
Author:
Ivanchenko V.1ORCID,
Ushakov A.1,
Gagarina A.1
Affiliation:
1. Department of Internal Medicine 1, Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal
University, Simferopol, Russian Federation
Abstract
Abstract:
Heart failure (HF) is a global healthcare burden and a leading cause of morbidity and
mortality worldwide. Type 2 diabetes mellitus (T2DM) appears to be one of the major risk factors
that significantly worsen HF prognosis and increase the risk of fatal cardiovascular outcomes. Despite
a great knowledge of pathophysiological mechanisms involved in HF development and progression,
hospitalization rates in patients with HF and concomitant T2DM remain elevated. In this
review, we discuss the complex interplay between systemic neurohumoral regulation and local
cardiac mechanisms participating in myocardial remodeling and HF development in T2DM with
special attention to cardiomyocyte energy metabolism, mitochondrial function and calcium metabolism,
cardiomyocyte hypertrophy and death, extracellular matrix remodeling.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,General Medicine