Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart-Reference-Cited by-同舟云学术

Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart

Published:2019-05-06 Issue:3 Volume:15 Page:177-187
ISSN:1573-403X
Container-title:Current Cardiology Reviews
language:en
Short-container-title:CCR

Author:

Maslov Leonid N.¹,Tsibulnikov Sergey Y.¹,Prokudina Ekaterina S.¹,Popov Sergey V.¹,Boshchenko Alla A.¹,Singh Nirmal²,Zhang Yi³,Oeltgen Peter R.⁴

Affiliation:

1. Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center of the Russian Academy of Science, Tomsk, Russian Federation

2. Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India

3. Department of Physiology, Hebei Medical University, Shijiazhuang, China

4. Department of Pathology, University of Kentucky College of Medicine, Lexington, KY, United States

Abstract

The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.

Funder

Russian Foundation of Basic Research

Russian Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,General Medicine

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