Interventions for Enuresis in Children and Adolescents: an Overview of Systematic Reviews

Author:

Moretti Eduarda1ORCID,da Silva Ivson Bezerra2ORCID,Boaviagem Alessandra3,de Lima Anna Myrna Jaguaribe4ORCID,Lemos Andrea5ORCID

Affiliation:

1. Physical Therapist and Master in Physiotherapy by the Federal University of Pernambuco. PhD in Child and Adolescent Health, Federal University of Pernambuco - Recife (PE), Brazil

2. Physical Therapist and PhD in Morphofunctional Science by the University of Sao Paulo. Professor at the Department of Morphology, Federal University of Paraiba - João Pessoa (PB), Brazil

3. Physical Therapist and Master in Physiotherapy by the Federal University of Pernambuco - Recife (PE), Brazil

4. Department of Animal Morphology and Physiology Federal Rural University of Pernambuco Brazil

5. Department of Physical Therapy, Federal University of Pernambuco. - Recife (PE), Brazil

Abstract

Background: enuresis is an involuntary and intermittent loss of urine during sleep and its treatment can be done by pharmacological and non-pharmacological strategies. Objective: to conduct an overview to carry out a survey of the systematic reviews about treatment options for children/adolescents with enuresis. Methods: Databases used were Cochrane Library, PROSPERO, MEDLINE/PubMed, EMBASE, LILACS/BVS, PEDro, SciELO and Google Scholar. Any type of intervention for the treatment of enuresis in children/adolescents were selected by two independent researchers. Data extraction was done by two independent researchers. The risk of bias was assessed using Risk of Bias in Systematic Reviews (ROBIS) and A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2). Results: seven systematic reviews were included. According to ROBIS, three reviews had a low risk of bias, while the others had a high risk of bias. Based on AMSTAR-2, four systematic reviews were of moderate quality, two were low quality and one was critically low quality. Conclusion: there is moderate confidence that the use of desmopressin plus an anticholinergic agent increases the chance of complete response compared to desmopressin alone. Neurostimulation may increase the risk of responses ≥50% and ≥90% compared to the control group. Likewise, it appears that electrical stimulation is superior to placebo about the chance of response ≥50%. In addition, there is the clinical relevance in reducing enuresis episodes per week when neurostimulation is used compared to control groups.

Publisher

Bentham Science Publishers Ltd.

Subject

Pediatrics, Perinatology and Child Health

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