Affiliation:
1. Department of Medicine DIMED, Nuclear Medicine Unit, University of Padua, Padua, Italy
2. Nuclear Medicine Unit,
Department of Oncological Medical and Specialists, University Hospital of Ferrara, Ferrara, Italy
3. Department of
Biomedical and Dental Sciences and of Morpho-functional Imaging, Nuclear Medicine Unit, University of Messina,
Messina, Italy
4. Nuclear Medicine Division, Salus Alliance Medical, Genoa, Italy
5. Department of Radiology, Massachusetts
General Hospital, Harvard Medical School, White Building Rm 250, 55 Fruit St, Boston, MA, 02114, USA
Abstract
Purpose:
The study aims to assess the role of SUVs, MTV, TLG, and other FDG PET metric
data in predicting the prognosis of patients with newly diagnosed BC.
Materials and methods:
A systematic review was conducted by using three different databases: Pub-
Med, Web of Science, and EMBASE, in the period between January 2011 and May 2021. Studies on
the use of FDG PET in BC patients concerning the utility of metric PET data and survival were retrieved.
The following keywords were used in diverse combinations: “breast cancer”, “18F-FDG”,
“FDG”, “PET”, “PET/CT”, “FDG PET”, “volumetric parameters”, “metabolic tumor volume”,
“MTV”, “total lesion glycolysis”, “TLG”, “prognosis”, “prognostic”. No limits were applied. The
quality of selected papers was assessed by using specific criteria.
Results:
Totally 123 articles were retrieved, but only 14 studies were selected. In the selected papers, overall, the number of patients was 1850. Overall survival (OS) was the main outcome in three studies, while both OS and disease-free survival (DFS) were considered in the remainder of most papers. PET/CT was performed in patients with BC, before surgery or neoadjuvant chemotherapy in 6 studies and in metastatic BC in 8. At multivariable analyses, diverse PET metrics, such as SUVmax, MTV and TLG were correlated to recurrence or OS. However, a large heterogeneity for the proposal cut-off, able to discriminate between poor and good prognosis, was found.
Conclusion:
Totally 123 articles were retrieved, but only 14 studies were selected. In the selected papers,
overall, the number of patients was 1850. Overall survival (OS) was the main outcome in three studies,
while both OS and disease-free survival (DFS) were considered in the remainder of most papers.
PET/CT was performed in patients with BC before surgery or neoadjuvant chemotherapy in 6 studies
and in metastatic BC in 8. At multivariable analyses, diverse PET metrics, such as SUVmax, MTV,
and TLG, were correlated to recurrence or OS. However, a large heterogeneity for the proposal cut-off,
able to discriminate between poor and good prognosis, was found.
Publisher
Bentham Science Publishers Ltd.
Subject
Radiology, Nuclear Medicine and imaging
Cited by
16 articles.
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