Comparing Perfusion Data of CE-MRI, SWI, and CTA with MR Perfusion in Stroke

Abstract

Background: To evaluate the perfusion status of patients with acute stroke, different imaging tools are used depending on the condition. CT-CT Angiography and MRI are indispensable imaging tools to diagnose and manage stroke patients. Susceptibility-weighted imaging (SWI) also has been used lately to evaluate vascular structures and consequences of stroke in the brain. We aimed to compare CE-MRI, SWI, and CTA with DSC-MRP in terms of perfusion. Methods: Stroke cases of CE-MRI, SWI, CTA and DSC-MRP of 44 patients were included. Collateralization was assessed on CTA; leptomeningeal-pial collateralization (LPC) and parenchymal enhancement (PE) on CE-MRI; prominent vessel sign (PVS) and hemorrhagic transformation on SWI. Results were compared with MRP maps and the ratio of penumbra/infarct core. Results: LPC was correlated with increased CBV (p<0,001), decreased CBF (p=0,026), and prolonged MTT and TTP (p=0,001 and p=0,003). LPC was observed more often in cases with infarct zones with penumbra compared to those without penumbra (p=0,024). PE was positively correlated with prolonged MTT and TTP (p=0,015 and p=0,031). Moreover, there was a positive relationship between PE and increased penumbra ratio over the infarct core (p=0,037). Ipsilateral PVS was associated with increased CBV (p=0,004) and decreased CBF (p=0,002). No relationship was found between collateralization grading on CTA and perfusion metrics or penumbra ratio. Conclusion: In conclusion; ipsilateral PVS can be a measure of CBV and CBF. LPC on CE-MRI can be a sign of an increase in CBV. PE can show larger penumbra. CE-MRI with SWI can be used to evaluate perfusion status.