Affiliation:
1. Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California San Diego,
San Diego, CA, USA
2. Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Objective:
Osteoarthritis (OA) is one of the most prevalent joint disorders in the world
that has placed an enormous economic and social burden on governments and healthcare sectors in
many countries. Hand OA (HOA) is the most common peripheral arthritis, which is less investigated
than knee and hip OA. Due to limited approved drug choices and adverse effects of long-term
use of current regimens, we aimed to review the existing evidence that were used as oral herbal
medicine to treat HOA.
Methods:
The PubMed database was searched for both observational and interventional studies
that have investigated herbal medicine safety and efficacy in HOA, written in English and published
between 2010 and 2022.
Results:
A total of 5 original articles fulfilled the inclusion criteria, and each article assessed a different
herbal regimen. Overall, it seems desirable to add specific herbal treatments to the regimen
of HOA patients, specifically in case of early stages of HOA.
Conclusion:
Currently, the need for a low-risk alternative treatment in HOA patients is felt more
than ever. There are reliable references relating to the safety of Korean red ginseng, GCSB-5, XLGB,
and GS-GCu in these patients, although their efficacy was limited. Additionally, herbs like curcumin
and Boswellia serrata have positively affected patients with knee osteoarthritis. However,
there is a lack of strong evidence supporting their effectiveness in hand osteoarthritis (HOA). This
emphasizes the potential benefits that these herbs may have for HOA patients.
Publisher
Bentham Science Publishers Ltd.
Reference45 articles.
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