Affiliation:
1. Department of Geriatrics, the Second Medical Center, Chinese PLA General Hospital, Beijing, 100853, China
Abstract
Abstract:
Induced pluripotent stem cells (iPSCs) are a type of pluripotent stem cells induced by somatic
cells. It was found that differentiated cells could be reprogrammed to a pluripotent state by the expression
of the four transcription factors such as Oct3/4, Sox2, c-Myc, and Klf4. This technology can be applied to
reprogramme the patient cells into iPSCs, which further be induced into research-required cells or tissues.
Nowadays, a great number of reprogramming methods and various types of somatic cells can be used to
produce iPSCs. The advancement of this technology provides a promising pathway to disease models
building, drug development, and the corresponding cell-based therapy.
Alzheimer's diseases (AD) and Parkinson's diseases (PD) are complex diseases affected by many factors,
including genetic and environmental factors. Until now, there are no effective treatments to reverse these
diseases because the pathogenesis of these complex diseases is still not well understood. One important
reason is that the existing disease model cannot fully recapitulate the pathologies of these multifactorial
associated diseases and iPSCs have the potential to resolve this difficulty. In this review, we discuss the
application progress of iPSCs in AD and PD, including disease modeling, drug development, and cellbased
therapies.
Funder
National Key R&D Program of China
National defense science and technology innovation projects
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)