Affiliation:
1. Department of Cardiac Surgery, The First Hospital of Jilin University, Changchun, 130021, China
Abstract
Abstract:
Heart failure is still the main complication affecting the prognosis of acute myocardial infarction
(AMI), and mesenchymal stem cells (MSCs) are an effective treatment to replace necrotic myocardium
and improve cardiac functioning. However, the transplant survival rate of MSCs still presents challenges.
In this review, the biological characteristics of MSCs, the progress of mechanism research in the
treatment of myocardial infarction, and the advances in improving the transplant survival rate of MSCs in
the replacement of necrotic myocardial infarction are systematically described. From a basic to advanced
clinical research, MSC transplants have evolved from a pure injection, an exosome injection, the genetic
modification of MSCs prior to injection to the cardiac tissue engineering of MSC patch grafting. This
study shows that MSCs have wide clinical applications in the treatment of AMI, suggesting improved
myocardial tissue creation. A broader clinical application prospect will be explored and developed to
improve the survival rate of MSC transplants and myocardial vascularization.
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
3 articles.
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