Affiliation:
1. Department of Pharmaceutical Sciences, Faculty of Health Sciences, Shalom Institute of Health and Allied Sciences (SIHAS), Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, 211007, Uttar Pradesh, India
Abstract
Background:
Plant-based products and their derivatives have been widely used in the medicine,
nutraceuticals, and the cosmetic and pharmaceutical field for a very long time. A large number of
important drugs of modern medicine have also been derived from the plant's sources. Plant products
specifically the pure phytochemical also known as ‘biomarkers’ have been used in the food and pharmaceutical
industries. Biomarker compounds are pure phytochemical and they are mainly responsible
for various pharmacological activities of plant material and examples of biomarker are Amarogentin,
Vasicine, Hyoscyamine and Paclitaxel.
Methods:
Various literature databases were searched to collect important information about Amarogentin
in this review. Ethnomedicinal uses, pharmacological activities, phytochemical aspects and modern
analytical tools of amarogentin were presented and discussed. Further, all the collected information’s
were categorized into different section as per the need of the manuscripts. Moreover, data were also
presented in the graphical abstract, Figures and Table section too.
Results:
Swertia chirata (S. chirata) is a common plant of Gentianaecae family which is mainly known
for their bitter taste. Gentiopicroside, amarogentin, swertiamarin, isovitexin and isogentisin are some
important phytoconstituents of S. chirata. Decoction, infusion, pastes and juice of S. chirata are basically
used in the medicine. Various Pharmacological activities such as hypoglycemic, antimicrobial,
antimalarial, antihepatotoxic, anticarcinogenic, antioxidative and anti-inflammatory have been reported
in the literature for S. chirata plant. Amarogentin, a bitter secoiridoid glycoside of S. chirata has been
well known for antibacterial, anticholinergic anti-lieshmanial, chemopreventive, antihepatitis and anticancer
activities.
Conclusion:
Information provided in the present paper regarding phytochemistry, pharmacological uses
and analytical aspects including bioavailability will be beneficial to various disciplines of biological
science. Development of plant tissue culture-based approaches is also needed for the proper conservation
of S. chirayita plants in the future.
Publisher
Bentham Science Publishers Ltd.
Subject
General Pharmacology, Toxicology and Pharmaceutics
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