Recent Advancements in Herbal Bioactive-based Nanoformulations for the Treatment of Psoriasis

Abstract

Abstract: Psoriasis is a multifaceted inflammatory dermatological skin disease characterized by Tcell (T-lymphocyte) activation, hyperproliferation, and abnormal epidermal keratinocyte differentiation. Natural bioactive agents from plants including Psoralea corylifolia, Nigella sativa, Curcuma longa, Capsicum annum, Smilax china, Woodfordia fructicosa, and others have recently gained a lot of attention for their anti-psoriatic properties. However, inadequate drug absorption, lack of specificity in drug release, and unintended skin reactions largely restrict their clinical efficacy. Nanoformulations improve the pharmacodynamic characteristics that overcome drug delivery challenges and enhance the anti-psoriatic activity. Nanostructured systems such as liposome, ethosome, liposphere, and others have been reported to improve plant extract solubility, penetration, bioavailability, bioactivity, and minimize undesirable effects, providing the way for the development of herbal nanoformulation. This review enlights the therapeutic efficacy of lead phytocompounds and its nanoformulations in managing psoriasis.