Affiliation:
1. Laboratorio de Toxicología Genética, Instituto Nacional de Pediatría, Coyoacán 04530, Mexico City, México
Abstract
Abstract:
Orphan cytochromes P450 (CYP) are enzymes whose biological functions and substrates are unknown.
However, the use of new experimental strategies has allowed obtaining more information about their relevance in the
metabolism of endogenous and exogenous compounds. Likewise, the modulation of their expression and activity has
been associated with pathogenesis and prognosis in different diseases. In this work, we review the regulatory pathways
and the possible role of orphan CYP to provide evidence that allow us to stop considering some of them as
orphan enzymes and to propose them as possible therapeutic targets in the design of new strategies for the treatment
of diseases associated with CYP-mediated metabolism.
Funder
Recursos Fiscales para Investigación, Instituto Nacional de Pediatría
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology