Affiliation:
1. Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China
Abstract
Background:
Genetic polymorphism has been proven to have an important association with
depression, which can influence the risk of developing depression, the efficacy of medications, and
adverse effects via metabolic and neurological pathways. Nonetheless, aspects of the association between
single nucleotide polymorphisms and depression have not been systematically investigated by
bibliometric analysis.
Objective:
The aim of this study was to analyze the current status and trends of single nucleotide polymorphism
research on depression through bibliometric and visual analysis.
Methods:
The Web of Science Core Collection was used to retrieve 10,043 articles that were published
between 1998 and 2021. CiteSpace (6.1 R4) was used to perform collaborative network analysis,
co-citation analysis, co-occurrence analysis, and citation burst detection.
Results:
The most productive and co-cited journals were the Journal of Affective Disorders and Biological
Psychiatry, respectively, and an analysis of the references showed that the most recent research
focused on the largest thematic cluster, “5-HT”, reflecting the important research base in this area.
“CYP2D6” has been in the spotlight since its emergence in 2009 and has become a research hotspot since
its outbreak in 2019. However, “BDNF ”, “COMT ”, “older adults”, “loci”, and “DNA methylation” are
also the new frontier of research, and some of them are currently in the process of exploration.
Conclusion:
These findings offer a useful perspective on existing research and potential future approaches
in the study of the association between single nucleotide polymorphisms and depression,
which may assist researchers in selecting appropriate collaborators or journals.
Funder
Science and Technology Plan Project of Guangdong Province
Medical Health Science and Technology Project of Guangzhou
Guangzhou Municipal Science and Technology Project for Medicine and Healthcare
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine