Affiliation:
1. Faculte de Medecine, Universite de Paris, Inserm UMR1141 NeuroDiderot, Paris, France
Abstract
Prematurity, observed in 15 million births worldwide each year, is a clinical condition
that is a major cause of neonatal mortality and morbidity in the short and long term. Preterm infants
are at high risk of developing respiratory problems, sepsis, and other morbidities leading to neurodevelopmental
impairment and neurobehavioral disorders. Perinatal glucocorticosteroids have been
widely used for the prevention and treatment of adverse outcomes linked to prematurity. However,
despite their short-term benefits due to their maturational properties, some clinical trials have shown
an association between steroids exposure and abnormal brain development in infants born preterm.
Neuroinflammation has emerged as a preeminent factor for brain injury in preterm infants, and the
major role of microglia, the brain resident immune cells, has been recently highlighted. Considering
the role of microglia in the modulation of brain development, the aim of this review is to summarize
the effects of endogenous and exogenous glucocorticosteroids on brain development and discuss the
possible role of microglia as the mediator of these effects.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
1 articles.
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