Affiliation:
1. Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of
Science and Technology, Wuhan, 430030, China
Abstract
Abstract:
Despite much research efforts being devoted to designing alternative pharmacological interventions,
chronic pain remains to be an unresolved clinical problem. Quercetin, a compound that
belongs to the flavonoids family, is abundantly found in fruits and vegetables. Emerging evidence
indicates that quercetin possesses anti-nociceptive effects in different rodent models of chronic pain,
including inflammatory pain, neuropathic pain and cancer pain. In this review, we summarize the
mechanisms underlying the analgesic effect of quercetin in preclinical studies. These studies showed
that quercetin exerts potent analgesic effects against chronic pain via suppressing neuroinflammation
and oxidative stress as well as modulation of synaptic plasticity, GABAergic system, and opioidergic
system. Considering that the safety of quercetin is well established, it has great potential for
clinical use in pain treatment.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
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