Affiliation:
1. Department of Biological Chemistry, Medical School,
National and Kapodistrian University of Athens, 11527 Athens, Greece
2. School of Medicine, University of Bologna, Bologna, Italy
Abstract
Abstract:
Tumor-associated macrophages (TAMs), the most plastic cells of the hematopoietic system,
exhibit increased tumor-infiltrating properties and functional heterogeneity depending on tumor
type and associated microenvironment. TAMs constitute a major cell type of cancer-related inflammation,
commonly enhancing tumor growth. They are profoundly involved in glioma pathogenesis,
contributing to many cancer hallmarks such as angiogenesis, survival, metastasis, and immunosuppression.
Efficient targeting of TAMs presents a promising approach to tackle glioma progression.
Several targeting options involve chemokine signaling axes inhibitors and antibodies, antiangiogenic
factors, immunomodulatory molecules, surface immunoglobulins blockers, receptor and
transcription factor inhibitors, as well as microRNAs (miRNAs), administered either as standalone
or in combination with other conventional therapies. Herein, we provide a critical overview of current
therapeutic approaches targeting TAMs in gliomas with the promising outcome.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine
Cited by
9 articles.
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