Affiliation:
1. School of Life Sciences, Northwestern Polytechnical University, Xi`an, China
2. College of Chemistry & Chemical Engineering, Xi`an Shiyou University, Xi`an, China
Abstract
Background:
As the quick development of modern methods and technologies currently, more and
more drugs have been invented with a better efficiency. However, the poor water solubility has limited the drugs’
pharmaceutical application.
Methods:
Tremendous research has been put in the design and development of nanocrystals for pharmaceutical
applications over the past few decades. The nanocrystals not only have the chance to solve the poor solubility
problem, but also could conquer the bioavailability and even the specific delivery problems. The physical properties
of drugs can be changed dramatically due to the change of their size in a nanodimension. Therefore, the
nanocrystals have great potential to overcome the challenge to design and development of new drugs for pharmaceutical
applications.
Results:
In this review, we provide an overview of the recent trends in nanocrystals for pharmaceutical applications.
Conclusion:
The current technologies including top-down, bottom-up, and combinative technologies for nanocrystals
were fully examined. Most importantly, the emphasis is put on the pharmaceutical applications including
their formulation, administration methods, safety, and toxicity. The commercial status, limitations, challenges,
and future trends of the nanocrystals for pharmaceutical applications were also discussed.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
12 articles.
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