Affiliation:
1. College of Medical Science, China Three Gorges University, Yichang 443002, China
Abstract
Background:
A number of studies have proposed that lncRNA XIST plays a role in the development
and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients.
The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.
Methods:
In this review, relevant researches involving the relationship between XIST and NSCLC are collected
through systematic retrieval of PubMed.
Results:
XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence
has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity
of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions
at transcriptional levels.
Conclusion:
LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic
target for NSCLC.
Funder
Health commission of Hubei Province
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
4 articles.
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