Affiliation:
1. Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
Abstract
Background:
Mounting evidence indicates that hydrogen gas (H2) is a versatile therapeutic agent,
even at very low, non-combustible concentrations. The Chinese National Health and Medical Commission recently
recommended the use of inhaled H2 in addition to O2 therapy in the treatment of COVID-19-associated
pneumonia, and its effects extend to anti-tumor, anti-inflammatory and antioxidant actions.
Summary:
In this review, we highlight key findings from preclinical researchn this review, we have highlighted key findings from preclinical research and recent clinical studies
demonstrating that H2 reduces the organ damage caused by ischemia-reperfusion. We have also outlined the
critical role this effect plays in a variety of medical emergencies, including myocardial infarction, hemorrhagic
shock, and out-of-hospital cardiac arrest, as well as in organ transplantation. H2 is compared with established
treatments such as targeted temperature management, and we have also discussed its possible mechanisms of
action, including the recently identified suppression of TNF-α-mediated endothelial glycocalyx degradation by
inhaled H2. In addition, our new method that enables H2 gas to be easily transported to emergency settings and
quickly injected into an organ preservation solution at the site of donor organ procurement have been described. and recent clinical studies demonstrating
that H2
reduces the organ damage caused by ischemia–reperfusion. We outline the critical role this effect plays in a variety
of medical emergencies, including myocardial infarction, hemorrhagic shock, and out-of-hospital cardiac arrest, as well as
in organ transplantation. H2
is compared with established treatments such as targeted temperature management, and we
discuss its possible mechanisms of action, including the recently identified suppression of TNF-α-mediated endothelial
glycocalyx degradation by inhaled H2
. In addition, we describe our new method that enables H2 gas to be easily
transported to emergency settings and quickly injected into an organ preservation solution at the site of donor organ
procurement.
Conclusion:
H2 is an easily administered, inexpensive and well-tolerated agent that is highly effective for a
wide range of conditions in emergency medicine, as well as for preserving donated organs.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
17 articles.
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