Phyto-targeting the CEMIP Expression as a Strategy to Prevent Pancreatic Cancer Metastasis

Abstract

Introduction: Metastasis of primary pancreatic cancer (PC) to adjacent or distant organs is responsible for the poor survival rate of affected individuals. Chemotherapy, radiotherapy, immunotherapy is being prescribed currently to treat PC in addition to surgical resection. Surgical resection is the preferred treatment for PC that leads to 20% of 5-year survival, but only less than 20% of patients are eligible for surgical resection, because of the poor prognosis. To improve the prognosis and clinical outcome, early diagnostic markers need to be identified, and targeting them would be of immense benefit to increase the efficiency of the treatment. Cell migration inducing hyaluron binding protein (CEMIP) is identified as an important risk factor for the metastasis of various cancers including PC. Emerging studies point out the crucial role forCEMIP in the regulation of various signaling mechanismleading to enhanced migration and metastasis of PC. Methods: The published findings in the area of pancreatic cancer metastasis, phyto-constituents and CEMIP were retrieved from Pubmed, Sciencedirect, Cochrane library. Computational tools such as gene expression profiling interactive analysis (GEPIA) and Kaplan–Meier (KM) plotter were used to study the relationship between CEMIP expression and survival of PC individuals. Results: Gene expression analysis using GEPIA database identified a stupendousincrease in the CEMIP transcript in PC when compared with adjacent normal tissue. KM plotter analysis revealed a critical role for CEMIP on the overall survival (OS) and disease-free survival (DFS) among PC patients. Subsequently several risk factors associated with the development of PC were screened and analyzed its ability to regulate CEMIP gene expression using computational tools. Conclusion: The current review is focused on gathering information about the regulatory role of phytocomponents on PC migration and exploring their possible impact on the CEMIP expression.