The Anti-atherosclerotic Effects of Natural Polysaccharides: From Phenomena to the Main Mechanisms of Action-Reference-Cited by-同舟云学术

The Anti-atherosclerotic Effects of Natural Polysaccharides: From Phenomena to the Main Mechanisms of Action

Published:2022-06 Issue:22 Volume:28 Page:1823-1832
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

I. Summerhill Volha¹,P. Karagodin Vasily²,Yet Shaw-Fang³,Orekhov Alexander N.¹⁴⁵

Affiliation:

1. Department of Basic Research, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia

2. Department of Commodity Research and Expertise, Plekhanov Russian University of Economics, 36 Stremyanny Pereulok, 117997 Moscow, Russia

3. Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan R.O.C

4. Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia

5. Laboratory of Infection Pathology and Molecular Microecology, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia

Abstract

Abstract: Polysaccharides (PSs) of plant origin have a variety of biological activities, including antiatherosclerotic, but their use in atherosclerosis therapy is hindered by insufficient knowledge based on the cellular and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of macrophages, viral activity and macrophage cholesterol metabolism has been discussed, considering the tight interplay between these aspects in the pathogenesis of atherosclerosis. The anti-atherosclerotic activities of natural PSs related to other mechanisms have also been explored. Directions for further research of the antiatherosclerotic effects of natural PSs have been outlined, the most promising of which can be nutrigenomic studies.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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