Affiliation:
1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Abstract
Abstract:
Non-small cell lung cancer (NSCLC) remains one of the deadliest malignant diseases, with high incidence
and mortality worldwide. The insulin-like growth factor (IGF) axis, consisting of IGF-1, IGF-2, related
receptors (IGF-1R, -2R), and high-affinity binding proteins (IGFBP 1-6), is associated with promoting fetal development,
tissue growth, and metabolism. Emerging studies have also identified the role of the IGF axis in
NSCLC, including cancer growth, invasion, and metastasis. Upregulation of IGE-1 and IGF-2, overexpression
of IGF-1R, and dysregulation of downstream signaling molecules involved in the PI-3K/Akt and MAPK pathways
jointly increase the risk of cancer growth and migration in NSCLC. At the genetic level, some noncoding
RNAs could influence the proliferation and differentiation of tumor cells through the IGF signaling pathway.
The resistance to some promising drugs might be partially attributed to the IGF axis. Therapeutic strategies targeting
the IGF axis have been evaluated, and some have shown promising efficacy. In this review, we summarize
the biological roles of the IGF axis in NSCLC, including the expression and prognostic significance of the
related components, noncoding RNA regulation, involvement in drug resistance, and therapeutic application.
This review offers a comprehensive understanding of NSCLC and provides insightful ideas for future research.
Funder
Natural Science Foundation of Guangdong Province
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
4 articles.
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