Affiliation:
1. Department of Chemistry, Bangladesh University of Engineering and Technology, Dhaka-1000, Bangladesh
2. Jeffrey Cheah School
of Medicine and Health Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Bandar Sunway Twnship, Malaysia
Abstract
Abstract:
The poor solubility, lack of targetability, quick renal clearance, and degradability of many therapeutic
and imaging agents strongly limit their applications inside the human body. Amphiphilic copolymers having
self-assembling properties can form core-shell structures called micelles, a promising nanocarrier for hydrophobic
drugs, plasmid DNA, oligonucleotides, small interfering RNAs (siRNAs), and imaging agents. Fabrication
of micelles loaded with different pharmaceutical agents provides numerous advantages, including therapeutic
efficacy, diagnostic sensitivity, and controlled release to the desired tissues. Moreover, their smaller particle
size (10-100 nm) and modified surfaces with different functional groups (such as ligands) help them to accumulate
easily in the target location, enhancing cellular uptake and reducing unwanted side effects. Furthermore, the
release of the encapsulated agents may also be triggered from stimuli-sensitive micelles under different physiological
conditions or by an external stimulus. In this review article, we discuss the recent advancements in formulating
and targeting of different natural and synthetic micelles, including block copolymer micelles, cationic
micelles, and dendrimers-, polysaccharide- and protein-based micelles for the delivery of different therapeutic
and diagnostic agents. Finally, their applications, outcomes, and future perspectives have been summarized.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献