Affiliation:
1. School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha
Abstract
Abstract:
Viral disease is a well-known cause of a significant impact on economic losses and threatens developed
and developing societies. High mutation rates and the lack of ability of conventional formulations to target
specific cells pose substantial hurdles to the successful treatment of viral diseases. We conducted a preliminary
search by a standard procedure. With hand searching, we conducted an advanced search across several electronic
databases. After defining the selection criteria, two writers independently reviewed and evaluated the first
500 abstracts before screening the remaining 300. Since there was 97% agreement on the screening decisions,
only one reviewer conducted the screening. The pre-planned data extraction process was accomplished, and the
thoroughness of the description of participation techniques was assessed. Additional data extraction was carried
out for articles with the most detailed illustrations. Four stakeholder representatives co-authored this systematic
review. Incorporating selective carbohydrate polymers into the antiviral pharmaceutical compositions could
help to manage biological complications associated with viral infections. We included 172 papers in which authors
were involved in a systematic review. The present review explains the role of carbohydrate polymers (chitosan,
carrageenan, alginate, cyclodextrin, dextran, and heparin) in the prevention and treatment of viral infections
in terms of their source, molecular weight, surface charge, chemical composition, and structure. Additionally,
the review describes the primary mechanism of drug delivery performance of carbohydrate polymers to
improve the antiviral properties and pharmacokinetic behaviour of lamivudine, zidovudine, acyclovir, etc. The
article discussed the role of carbohydrate polymers in mitigating virus-induced associated complications like
bacterial infection, cardiovascular disorder, oxidative stress, and metabolic disorder. As a result, this work will
provide valuable information to scientists, researchers, and clinicians for suitable carbohydrate polymer-based
pharmaceutical development.
Funder
Department of Biotechnology, Government of India
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology