Affiliation:
1. Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States
Abstract
Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular
function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium
is also the barrier for insulin movement into tissues, it acts as a gatekeeper for transport and glucose uptake.
For this reason, endothelial dysfunction is a tempting area for pharmacological and/or exercise intervention with
insulin-based therapies. In this review, we describe the current state of drugs that can be used to treat endothelial
dysfunction in type 2 diabetes and diabetes-related diseases (e.g., obesity) at the molecular levels, and also discuss
their role in exercise.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
3 articles.
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