Affiliation:
1. Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514- 8507, Japan
Abstract
:
Sepsis is the leading cause of death in medical intensive care units, and thus represents a serious
healthcare problem worldwide. Sepsis is often caused by the aberrant host responses to infection, which induce
dysregulated inflammation that leads to life-threatening multiple organ failures. Mediators such as proinflammatory
cytokines that drive the sepsis pathogenesis have been extensively studied. Exosomes, biological
lipid bilayer nanoparticles secreted via the endosomal pathway of cells, have recently emerged as important cargos
that carry multiple mediators critical for the pathogenesis of sepsis-associated organ dysfunctions. Here we
will review current knowledge on the exosomes in sepsis and relevant inflammatory tissue injuries.
Funder
Japan Society for the Promotion of Science
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
27 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献