Copper and Neurotoxicity in Autism Spectrum Disorder

Author:

Santos Gesivaldo1ORCID,Borges Julita M.P.2ORCID,Avila-Rodriguez Marco3ORCID,Gaíno Silvana B.4ORCID,Barreto George E.5ORCID,Rúbio Érika P.2ORCID,Aguiar Rosane M.2ORCID,Galembeck Eduardo6ORCID,Bromochenkel Cattiúscia B.7ORCID,de Oliveira Djalma M.2ORCID

Affiliation:

1. Department of Biological Science, State University of Southwestern of Bahia, Bahia, Brazil

2. Department of Science and Technology, State University of Southwestern of Bahia, Bahia, Brazil

3. Department of Clinical Science, Universidad del Tolima-Tolima, Colombia

4. Federal University of Reconcavo Bahia, Bahia, Brazil

5. Department of Biological Sciences, University of Limerick, Limerick, Ireland

6. Institute of Biology, State University of Campinas-São Paulo, São Paulo, Brazil

7. Department of Psychology, Faculty of Science and Technology, Bahia, Brazil

Abstract

: Free radicals (FR) act on living organisms and present unpaired electrons in the molecular orbitals of oxygen or nitrogen species. They are classified as redox reactions and account for a wide range of processes in biological systems. Genetic and environmental factors may alter the levels of FR in the cell, leading to deleterious consequences such as membrane lipid peroxidation, protein nitration, enzyme, carbohydrate and DNA damage, ultimately resulting in premature aging and a pro-inflammatory microenvironment as observed in Alzheimer’s disease (AD) and autism spectrum disorder (ASD). O2 radical ability to act as a Lewis base and to form a complex with metal transition such as iron and copper (Lewis acids) leads to biomolecules oxidation at physiological pH, thus increasing the possibility of injury and oxidative damage in biological tissues. In this review, we discuss the role of metals, like copper, and the amyloid precursor protein (APP) derivative (s-APP-alpha) as an antioxidant and a possible adjuvant in the treatment of some autistic spectrum disorder symptoms (ASD).

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3