Affiliation:
1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China
Abstract
Conclusion:
Patients with RA have lower circulating IGF-1 level than healthy controls, particularly for patients
from Asia and Europe. Further studies are necessary to elucidate the role of IGF-1 in the pathological process of
RA.
Results:
A total of eleven articles with 334 cases and 261 controls were finally included. Compared with the
healthy group, the RA group had lower circulating IGF-1 levels (pooled SMD= -0.936, 95% CI= -1.382 to -0.489,
p<0.001). The subgroup analysis showed that RA patients from Asia (SMD= -0.645, 95% CI= -1.063 to -0.228,
p= 0.002) and Europe (SMD= -1.131, 95% CI= -1.767 to -0.495, p<0.001) had lower circulating IGF-1 levels, no
significant difference in plasma/serum IGF-1 levels was observed in RA patients from America. Sensitivity
analysis indicated the stability and credibility of the overall effect sizes.
Methods:
PubMed, Embase and the Cochrane Library databases were searched up to December 2018 in English,
and the studies comparing serum/plasma IGF-1 levels between RA group and healthy control group were what we
are interested in. The Newcastle-Ottawa Scale (NOS) was used to assess the methodological quality of the
included studies. The heterogeneity test was performed by the Cochrane Q statistic and I2 –statistic. The publication
bias was evaluated by the funnel plot and Egger’s test. The standard mean difference (SMD) with 95% confidence
interval (CI) was calculated by the fixed-effects or random-effects model.
Background and Objectives:
Insulin-like growth factor-1 (IGF-1) levels have been investigated in
rheumatoid arthritis (RA), however, produced inconsistent results. The purpose of this meta-analysis was to derive
a more precise conclusion about serum/plasma IGF-1 levels in RA patients.
Funder
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
4 articles.
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