Affiliation:
1. Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
Abstract
Abstract:
Coffee is one of the most popular beverages in the world, with potential health benefits
and anti-diabetic qualities. Numerous bioactive substances found in coffee have been studied for
their possible therapeutic benefits in controlling blood glucose. Given the ubiquitous use of coffee,
this article aims to review the anti-diabetic characteristics of various coffee bioactive compounds
such as chlorogenic acids, caffeic acid, quinic acid, ferulic acid, and caffeine. The modulation
of glucose homeostasis, improvement of insulin sensitivity, suppression of gluconeogenesis,
anti-inflammatory properties, and antioxidant activity are only a few of the several mechanisms of
action that have been suggested. These qualities allow coffee polyphenols to potentially have antidiabetic
effects, opening the door to prospective medicinal uses. The molecular mechanisms underpinning
the effects of coffee polyphenols on insulin signaling pathways and glucose metabolism
have been clarified by in vitro investigations. In animal studies, coffee polyphenols have positively
affected pancreatic function, insulin resistance, and glucose regulation. Human studies have
linked drinking coffee to a lower incidence of type 2 diabetes, better glycaemic management, and
increased insulin sensitivity.
Publisher
Bentham Science Publishers Ltd.