Affiliation:
1. Department of Biochemistry, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal, Madhya
Pradesh, India
Abstract
Abstract:
Non-alcoholic fatty liver disease is a globally prevalent disorder that can
rapidly progress if not detected early. Currently, no accepted markers exist for early
diagnosis and prognosis of NAFLD. This review describes derangement in major
metabolic pathways of lipid, carbohydrate, and amino acids in NAFLD. It suggests that
measuring levels of thrombospondin, TyG index, asymmetric dimethylarginine, LAL-A,
GLP-1, FGF-21, and GSG index are potential markers for early diagnosis of NAFLD. A
single marker may not indicate early NAFLD, and further large-scale studies on
correlating levels of Thrombospondin-2, triglyceride-glucose index, and FGF-21 with
NAFLD are warranted.
Publisher
Bentham Science Publishers Ltd.