Role of Nitric Oxide in Diabetic Wound Healing-Reference-Cited by-同舟云学术

Role of Nitric Oxide in Diabetic Wound Healing

Published:2022-11-29 Issue: Volume: Page:128-160
ISSN:
Container-title:The Role of Nitric Oxide in Type 2 Diabetes
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Author:

Afzali Hamideh¹,Ranjbar Tara²,Kashfi Khosrow³,Ghasemi Asghar⁴

Affiliation:

1. Shahid Beheshti University of Medical Sciences,Endocrine Physiology Research Center, Research Institute for Endocrine Sciences,Tehran,Iran

2. City University of New York School of Medicine,Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education,New York, NY 10031, USA,New York,United States

3. City University of New York School of Medicin,Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education,New York, NY 10031, USA,New York,,United States

4. Shahid Beheshti University of Medical Sciences,Endocrine Physiology Research Center, Research Institute for Endocrine Sciences,,Tehran,Iran

Abstract

Nitric oxide (NO), a gaseous free radical, is a key signaling molecule in the different phases of the normal wound healing process. The beneficial effects of NO in wound healing are related to its antibacterial properties, regulation of inflammatory response, stimulation of proliferation and differentiation of keratinocytes and fibroblasts, and promotion of angiogenesis and collagen deposition. NO deficiency is an important mechanism responsible for poor healing in diabetic wounds. In this chapter, the function of NO in diabetic wound healing and the possible therapeutic significance of NO in the treatment of diabetic wounds are discussed. Current knowledge supports this notion that NO-based intervention is a promising therapeutic approach for diabetic wound healing.

Publisher

BENTHAM SCIENCE PUBLISHERS

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