Biomedical and Biotechnological Potential of Animal Venoms: Bothrops Snake Venoms and their Antimicrobial Applications

Author:

Reimann Raissa1ORCID,Barreto Breno1ORCID,Romano Filippo1ORCID,Medeiros Jade1ORCID,Camargo Bruna C.1ORCID,N. da Silva Josiel1ORCID,Soares Ana Luiza B.1,F. de Souza Mateus23,Macedo Jamile M.23,Kayano Anderson M.234,Zuliani Juliana P.3,N. de Oliveira Ana3,L. da Silva Saulo35,Diniz-Sousa Rafaela13,Soares Andreimar M.1233ORCID

Affiliation:

1. Curso de Medicina, Centro Universitário São Lucas, SÃO LUCAS PVH, Porto Velho-RO, Brazil

2. Fundação Oswaldo Cruz, FIOCRUZ, Fiocruz Rondônia, Porto Velho-RO, Brazil

3. Rede de Pesquisa e Conhecimento de Excelência na Amazônia Ocidental, RED-CONEXAO, Brazil

4. Centro de Medicina Tropical, CEPEM, SESAU-RO, Porto Velho-RO, Brazil

5. LAQV/Requimte, University of Porto, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal

Abstract

Abstract: The pursuit of novel treatment alternatives to address the accumulated resistance to antimicrobials over the years has prompted the scientific community to explore biodiversity, particularly animal venom, as a potential source of new antimicrobial drugs. Snake venoms, with their complex mixtures of components, are particularly promising targets for investigation in this regard. The search for novel molecules exhibiting antimicrobial activity against multidrug-resistant strains is of paramount importance for public health and numerous research groups worldwide. High expectations within the healthcare field are supported by the scientific literature, which highlights the potential development of innovative drugs through in vivo and in vitro application, depending on dose titration. Snake venoms and their molecules and peptides offer exponential possibilities for biotechnological applications as antimicrobial agents. However, many uncertainties and unexplored avenues remain, presenting opportunities for discoveries and research.

Publisher

Bentham Science Publishers Ltd.

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